Or about how something works: Comprehension usually used with of. Knowledge about a subject, situation, etc.
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Both comprehension and understanding can be used to talk about someone's ability to understand something. Understanding is a relation between the knower and an object of understanding. The meaning of understanding is a mental grasp :
How to use understanding in a sentence.
He noted bond's apparent lack of. Understanding a concept means you get it. Understanding implies abilities and dispositions with respect to an object. Your understanding might be that your mother will always drive you to school if you miss the bus.