Understanding implies abilities and dispositions with respect to an object. Or about how something works: He noted bond's apparent lack of.
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Both comprehension and understanding can be used to talk about someone's ability to understand something. Your understanding might be that your mother will always drive you to school if you miss the bus. Understanding is a relation between the knower and an object of understanding.
How to use understanding in a sentence.
Understanding a concept means you get it. The meaning of understanding is a mental grasp : Comprehension usually used with of. Knowledge about a subject, situation, etc.