Comprehension usually used with of. How to use understanding in a sentence. Understanding is a relation between the knower and an object of understanding.
Massachusetts Executive Office of Housing and Livable Communities
Both comprehension and understanding can be used to talk about someone's ability to understand something. Knowledge about a subject, situation, etc. Understanding implies abilities and dispositions with respect to an object.
The meaning of understanding is a mental grasp :
He noted bond's apparent lack of. Or about how something works: Understanding a concept means you get it. Your understanding might be that your mother will always drive you to school if you miss the bus.